DFG Priority Programme: "Exit Strategies of Intracellular Pathogens"

Many pathogens exist for a certain period of time or for propagation within host cells. However, they have to leave the host cell to continue their life cycle. Therefore, the exit from the host cell is closely linked to microbial pathogenesis and is crucial for the spread of the disease. The aim of the research in the Priority Programme is to investigate the exit strategies of pathogens, including infectious agents of diseases such as malaria, tuberculosis and typhoid fever. Therefore, the spectrum of pathogen exit pathways will be characterized, the molecular mechanisms mediating the exit from the host cell will be identified, and the relationship between exit strategy and disease progression will be uncovered.

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Research at ZAI

In the research group of Prof. Pradel we focus on the molecular cell biology of the human malaria pathogen Plasmodium falciparum. The expertise of our group lies in particular on the gametocytes which are important for the transmission of malaria. In our projects we focus on both basic and applied aspects of malaria research.

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An overview of the publications of our working group in different scientific journals is provided as well.

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SPP 2225: EXIT Strategies

The SPP 2225 aims at exploring the spectrum of convergently evolved exit pathways employed by bacterial, parasitic and fungal pathogens with relevance for human health. Knowledge gained by the SPP 2225 will extend our understanding of microbial pathogenesis and help to explore novel targets for future interventional measures to counteract human infectious diseases.

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