Curriculum vitae Dr. Che Julius Ngwa

  Dr. Che Julius Ngwa Copyright: Julius Ngwa

Education

Oct 25, 2013: Ph.D Natural Sciences, Infection and Immunity, Graduate School of Life sciences, University of Würzburg, Germany. Thesis title: The mosquito midgut-specific stages of the malaria parasite as targets for transmission blocking interventions.

Mar 27, 2007: M.Sc in Biochemistry, University of Buea, Department of Biochemistry and Microbiology, Cameroon.

Aug 05, 2004: B.Sc (Hons) in Biochemistry and minor in medical laboratory technology, University of Buea, Department of Biochemistry and Microbiology, Cameroon.

Professional Experience

Since 01/2019: Group leader, Section of Cellular and Applied Infection Biology, RWTH Aachen University.

12/2013-12/2018: Post-doctoral researcher and lecturer at RWTH Aachen University.

03-04/2015: Visiting Scientist, Research School of Biology (RSB), Australian National University, Canberra, Australia

09-11/2014: Visiting Scientist, Department of Biochemistry and Molecular Biology, Pennsylvania State University, Pennsylvania, USA.

01/2007-03/2010: Research Scientist, Research Foundation for Tropical Diseases and Environment, Buea, University of Buea, Cameroon.

10/2009-01/2010: Part-time Lecturer, Department of Biochemistry and Microbiology, University of Buea, Cameroon.

Awards and Fellowships

01/2016: Awarded the DFG Excellent Initiative-ERS RWTH University Start-Up grant to foster scientific autonomy and profile.

02/2014: Awarded the Theodore von Kármán grant for outgoing scientists from the RWTH Aachen University.

02/2013: Recipient of the German Society for Hygiene and Microbiology (DGHM) Eukaryotic Pathogen travel scholarship.

09/2012: Recipient of the German Society for Hygiene and Microbiology conference travel scholarship.

05/2010: Awarded German Excellence Initiative PhD fellowship at the Graduate School of Life Sciences, University of Würzburg, Germany.

03/2009: Recipient of the American Society of cell Biology course scholarship to attend the First West African Regional Workshop on Cell Biology at the University of Ghana.

02/2009: Received the International Centre for Genetic Engineering and Biotechnology (ICGEB) partial scholarship to attend the “Molecular Medicine and Genomics in African theoretical course in Zanzibar, Tanzania.

03/2004: Excellence scholarship granted by the Ministry of Higher Education to outstanding students of the University of Buea, Cameroon.

Additional training and workshops

03-04/2015: Genetic manipulation of Plasmodium falciparum, Australian National University Canberra, Australia.

09-11/2014: Microarray experimentation and analysis, Penn State University, USA.

03/2012: “Writing grant proposals” course at the University of Würzburg, Germany.

07/2011: Training on Animal handling methods” at the University of Würzburg, Germany.

09-10/2010: Statistics course part I and II at the University of Würzburg, Germany.

12/2010-01/2011: Training course on histopathology at the Research Foundation for Tropical Diseases and Environment Buea/University of Buea, Cameroon.

07/2009: Training course on the Cell Biology of Eukaryotic pathogens at the University of Ghana.

Third Party Fundings:

2019-2022: DFG grant. Functional characterization of potential epigenetically regulated zinc finger proteins important for malaria parasite transmission (226,710 EUR).

2017-2018: ERS Dean´s Seed Fund, RWTH Aachen University. Comparative mapping of the DNA-methylation status in the blood and transmission stages of the malaria parasite Plasmodium falciparum using nanopore sequencing (47,900 EUR).

2016-2017: ERS RWTH Aachen Start up grant. Characterization of a potential epigenetic regulator important for malaria parasite transmission (20,000 EUR).

Publications

Bennink S, von Bohl A, Ngwa CJ, Henschel L, Kuehn A, Pilch N, Weißbach T, Rosinski AN, Scheuermayer M, Repnik U, Przyborski JM, Minns AM, Orchard LM, Griffiths G, Lindner SE, Llinás M, Pradel G.(2018). A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum. PLoS Pathog. doi: 10.1371/journal.ppat.1007249.

Ngwa CJ, Kiesow MJ, Papst O, Orchard LM, Filarsky M, Rosinski AN, Voss TS, Llinás M, Pradel G. (2017).Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparum. Front Cell Infect Microbiol. doi: 10.3389/fcimb.2017.00320.

Wanji S, Eyong EJ, Tendongfor N, Ngwa CJ, Esuka EN, Kengne-Ouafo AJ, Datchoua-Poutcheu FR, Enyong P, Agnew D, Eversole RR, Hopkins A, Mackenzie CD. (2017). Ivermectin treatment of Loa loa hyper-microfilaraemic baboons (Papio anubis): Assessment of microfilarial loads, haematological and biochemical parameters and histopathological changes following treatment. PLoS Negl Trop Dis. doi: 10.1371/journal.pntd.0005576.

Weißbach T, Golzmann A, Bennink S, Pradel G, Ngwa CJ (2017).Transcript and protein expression analysis of proteases in the blood stages of Plasmodium falciparum. Exp Parasitol. doi: 10.1016/j.exppara.2017.03.006.

Philbert A, Lyantagaye S, Pradel G, Ngwa CJ, Nkwengulila G (2017). Pyrethroid and DDT tolerance of Anopheles gambiae s.l. from Sengerema District, an area of intensive pesticide usage in northwestern Tanzania.Tropical Medicine & International Health. DOI: 10.1111/tmi.12850.

Ngwa CJ, Rosa T, Pradel G (2016).The Biology of Malaria Gametocytes. Current Topics in Malaria, Dr. Alfonso Rodriguez-Morales (Ed.), InTech, DOI: 10.5772/65464. Available from: http://www.intechopen.com/books/current-topics-in-malaria/the-biology-of-malaria-gametocytes.

Schmidt I, Pradel G, Sologub L, Golzmann A, Ngwa CJ, Kucharski A, Schirmeister T, Holzgrabe U (2016). Bistacrine derivatives as new potent antimalarials. Bioorg Med Chem. doi: 10.1016/j.bmc.2016.06.003.

Rosa TF, Flammersfeld A, Ngwa CJ, Kiesow M, Fischer R, Zipfel PF, Skerka C, Pradel G (2016).The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement. Cell Microbiol 18(4):573-90.

Wanji S, Eyong EE, Tendongfor N, Ngwa C, Esuka E, Kengne-Ouafo A, Datchoua-Poutcheu F, Enyong P, Hopkins A, Mackenzie CD (2015). Parasitological, Hematological and Biochemical Characteristics of a Model of Hyper-microfilariaemic Loiasis (Loa loa) in the Baboon (Papio anubis). PLoS Negl Trop Dis. 10:9(11):e0004202

Ngwa C.J, Pradel G (2014). Coming soon: probiotics-based malaria vaccines.Trends Parasitol 31(1):2-4.

Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Ngwa CJ, Moecking J, Goodman CD, McFadden GI, Sumanadasa SD, Fairlie DP, Avery VM, Kurz T, Andrews KT (2014). Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules. Antimicrob Agents Chemother 58(7):3666-3678.

Ngwa CJ, Scheuermayer M, Mair GR, Kern S, Brügl T, Wirth CC, Aminake MN, Wiesner J, Fischer R, Vilcinskas A, Pradel G.(2013). Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito. BMC Genomics 14:256.

Ngwa CJ, Glöckner V, Abdelmohsen UR, Scheuermayer M, Fischer R, Hentschel U, Pradel G. (2013). 16S rRNA gene-based identification of Elizabethkingia meningoseptica as a dominant midgut bacterium of the Asian malaria vector Anopheles stephensi with antimicrobial activities. J. Med. Entomol. 50:404-414.

Röhrich CR, Ngwa CJ, Wiesner J, Schmidtberg H, Degenkolb T, Kollewe C, Fischer R, Pradel G, Vilcinskas A (2012). Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity. BiolLett. 8:308–311.

Tendongfor N, Wanji S, Ngwa JC, Esum ME, Specht S, Enyong P, Matthaei KI, Hoerauf A (2012). The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization. Parasit. Vectors 5:43.

Wanji S, Tendongfor N, Nji T, Esum M, Che JN, Nkwescheu A, Alassa F, Kamnang G, Enyong PA, Taylor MJ et al. (2009). Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon. Parasit. Vectors 2(1):39.

Wanji S, Tendongfor N, Esum M, Che JN, Mand S, Tanga Mbi C, Enyong P, Hoerauf A(2008). Elephantiasis of non-filarial origin (podoconiosis) in the highlands of North-Western Cameroon. Ann. Trop. Med. Parasitol. 102:1-12.