Curriculum vitae Prof. Gabriele Pradel

  Prof. Dr. Gabriele Pradel Copyright: G. Pradel

Born April 8, 1970, in Bocholt, Germany, married, two children *2002, *2008

Education

19/12/2012: Venia Legendi in Microbiology and Molecular Biotechnology

RWTH Aachen University, Germany

12/11/2008: Habilitation in Cell and Microbiology

Julius Maximilians University Würzburg, Germany

• Thesis: Transmission stage proteins of the malaria parasite Plasmodium sp. and their roles for intervention strategies.

26/01/1999: Dr. phil. nat.

Johann Wolfgang Goethe University Frankfurt am Main, Germany

• Thesis: Neural cell adhesion molecules in long-term memory formation after active avoidance conditioning in zebrafish.

14/07/1994: Diploma in Biology

Justus Liebig University Gießen, Germany

• Thesis: Ultrastructural examinations of the fine structure of Plasmodium chabaudi during Artemisinin treatment in vitro.

Professional Experience

Since 04/2019: University Professor (W2)

Division of Cellular and Applied Infection Biology, RWTH Aachen University, Germany

04/2014-03/2019: Heisenberg Professor

Division of Cellular and Applied Infection Biology, RWTH Aachen University, Germany

04/2012-06/2018: Project Group Leader

Fraunhofer Institute for Molecular Biology and Applied Ecology Aachen, Germany

01/2012-03/2014: Group Leader

Institute of Molecular Biotechnology, RWTH Aachen University, Germany

01/2005-12/2011: Emmy Noether Group Leader

Research Center for Infectious Diseases, Julius Maximilians University Würzburg, Germany

08/2003-02/2005: Instructor

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, USA

09/2001-07/2003: Postdoctoral Associate

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, USA

03/1999-08/2001: Postdoctoral Fellow

Department of Medical and Molecular Parasitology, NYU School of Medicine, New York, USA

Awards and Fellowships

07/2019: Recipient of the PAULA award (category “best lecture”) of the RWTH Aachen University medical student union for excellent teaching

02/2018: Recipient of the “Hauptpreis”, German Society for Hygiene and Microbiology (DGHM)

07/2017: Recipient of the PAULA award (category “best organization”) of the RWTH Aachen University medical student union for excellent teaching

11/2012: Awarded by the Heisenberg Programme of the DFG

06/2010: Selected for AcademiaNet by the Robert-Bosch-Foundation

03/2010: Recipient of the Karl Asmund Rudolphi Medal, German Society for Parasitology (DGP)

01/2005: Awarded by the Emmy Noether Programme of the DFG

09/2000-08/2001: Recipient of a Postdoctoral Fellowship of the Karl-Enigk-Foundation

03/1999-08/2000: Recipient of a Postdoctoral Fellowship of the DAAD

Third Party Funding

Total funding volume: 4.3 million EUR

2019-2022: Project "The role of the scaffolding protein WLP1 in maintaining multiprotein complexes of malaria gametocytes", DFG.

2017-2020: Project “Factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum”, DFG.

2017-2019: Heisenberg grant “Proteins of the human malaria parasite Plasmodium falciparum as targets for malaria therapy”, DFG.

2017: Dean´s Seed Fund “Design of an easy-to-use impregnating agent based on organic compounds to prevent mosquito bites from the Malaria vector Anopheles”, RWTH Aachen University.

2015-2017: Project “The egress of malaria gametocytes from the red blood cell following parasite transmission to the mosquito”, priority programme SPP1580/2 “Intracellular compartments as places of pathogen-host-interaction”, DFG.

2014-2016: Project “GC-GENES: Gene correlation studies in the gametocytes of the malaria parasite Plasmodium falciparum”, BMBF.

2014: Dean´s Seed Fund “Relocation of the transmembrane protein PfGAP50 during complement evasion by the malaria parasite Plasmodium falciparum” RWTH Aachen University.

2014-2017: Heisenberg grant “Sexual stage-specific proteins of the human malaria parasite Plasmodium falciparum and their role for transmission blocking proteins”, DFG.

2014-2017: Project “The epigenetic control of gene expression in malaria gametocytes during transmission from the human to the mosquito“; DFG.

2012-2015: Project “The assembly of multimeric protein complexes in the sexual stages of the human malaria parasite Plasmodium falciparum”, DFG.

2012-2014: Project “The egress of malaria gametocytes from the red blood cell following parasite transmission to the mosquito”, priority programme SPP1580/1 “Intracellular compartments as places of pathogen-host-interaction”, DFG.

2010-2014: Project “Functional evaluation of vaccine candidates against the sexual stages of Plasmodium parasites“, Fraunhofer Future Foundation Malaria Project.

2009-2012: Member of the MALSIG consortium “Signalling in life cycle stages of malaria parasites”, EU 7th Framework Programme.

2008-2012: Project 9 “Generation and characterization of candidates for malaria/HIV combination therapy”, International Research Training Group IRTG 1522 “HIV/AIDS and associated infectious diseases in South Africa”, DFG.

2007-2011: Associated member of BioMedTec International Graduate School of Science „Lead structures of cell function”, Elite Network Bayern.

2007-2011: Associated member of the SFB 630 „Recognition, preparation and functional analysis of agents against infectious diseases”, DFG.

2007-2009: Project B8 “Identification of molecular interactions during fertilization in the malaria pathogen Plasmodium falciparum“, SFB 479 “Pathogen Variation and Host Response in Infectious Diseases“, DFG.

2005-2011: Emmy Noether grant “Characterization of a novel multi-adhesion protein family expressed in the sexual stages of the human malaria pathogen Plasmodium falciparum”, DFG.

Additional Scientific Activities

  • Board member of the German Society for Parasitology (2014-2018)
  • Vice Speaker of the Eukaryotic Pathogens Section of the German Society of Hygiene and Microbiology (2015-2017)
  • Member of the Examinations board of the Department of Biology (since 2016)
  • Member of the DAAD Selection Committee for Eastern Europe (since 2015)
  • Mentor of the Studienstiftung des deutschen Volkes for students of RWTH Aachen University (since 2015)
  • Mentor at the RWTH Aachen University Tandem Programme (2014-2016)
  • Board member of the Biomedical Graduate School Aachen of RWTH Aachen University (since 2017)
  • Board member of the Aachen Center of Young Researchers of RWTH Aachen University (2012-2014)
  • Speaker of the class “Infection and Immunity”, Graduate School of Life Science, University of Würzburg (2008-2011)
  • Officer for Biological Safety at Research Center for Infectious Diseases, University of Würzburg (2007-2011)
  • Organizer of the following meetings: Malaria Meeting Aachen (2013), Gametocyte Meeting Aachen (2014), DGHM-Workshop “Eukaryotic Pathogens“ Aachen (2016), DGP-Meeting Göttingen (2016), BioMalPar Heidelberg (2017)
  • Member of the following societies: Deutsche Gesellschaft für Parasitologie (German Society for Parasitology), Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology), Deutscher Hochschulverband
  • Peer reviewer for funding agencies including Wellcome Trust (UK), Medical Research Council (UK), DFG (Germany), DAAD (Germany), ERC and EURYI (EU)
  • Editor of PLoS One and Guest Editor of PLoS Pathogens (since 2012)
  • Peer reviewer for journals including Nature, EMBO Journal, PNAS, Cell Host & Microbe, PLoS Pathogens, Molecular Microbiology, Cellular Microbiology, Cellular and Molecular Life Sciences, PLoS One, Trends in Parasitology, Future Microbiology, Biochemistry Journal, Biological Chemistry, Infection and Immunity, International Journal for Parasitology, Molecular and Biochemical Parasitology, Malaria Journal, Experimental Parasitology and International Journal for Medical Microbiology

Publications

H-Index: 33; i10-Index: 62 (December 2018, Google Scholar)

62 peer-reviewed original publications, 16 reviews, 4 book chapters, 2 proceedings, 2 patents

Including: Science, Cell Host Microbe, J Exp Med, Nat Commun, Cell Res, Hepatol, Cell Microbiol, PLoS Pathog

10 selected Publications

Bennink, S., von Bohl, A., Ngwa, C.J., Henschel, L., Kuehn, A., Pilch, N., Weißbach, T., Rosinski, A.N., Scheuermayer, M., Repnik, U., Przyborski, J.M., Minns, A.M., Orchard, L.M., Griffiths, G., Lindner, S.E., Llinás, M., Pradel, G. (2018). A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum. PLoS Pathog 14:e1007249.

Ngwa, C.J., Kiesow, M.J., Pabst, O., Orchard, L.M., Filarsky, M., Rosinski, A.N., Voss, T.S., Llinás, M., Pradel, G. (2017). Transcriptional profiling defines Histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum. Front Cell Infect Microbiol 7:320

Wirth CC, Glushakova S, Scheuermayer M, Repnik U, Garg S, Schaack D, Kachman MM, Weißbach T, Zimmerberg J, Dandekar T, Griffiths G, Chitnis CE, Singh S, Fischer R, Pradel G (2014):
Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes.
Cell Microbiol 16:709-733.

Simon N, Lasonder E, Scheuermayer M, Kuehn A, Tews S, Fischer R, Zipfel PF, Skerka C, Pradel G (2013):
Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.
Cell Host Microbe 13(1):29-41.

Rupp I, Sologub L, Williamson KC, Scheuermayer M, Reininger L, Doerig C, Eksi S, Kombila DU, Frank M, Pradel G (2011):
Malaria parasites form filamentous cell-to-cell connections during reproduction in the mosquito midgut.
Cell Res 21:683-696.

Simon N, Scholz SM, Moreira CK, Templeton TJ, Kuehn A, Dude MA, Pradel G (2009):
Sexual stage adhesion proteins form multi-protein complexes in the malaria parasite Plasmodium falciparum.
J Biol Chem 284:14537-14546.

Pradel G, Hayton K, Aravind L, Iyer LM, Abrahamsen MS, Bonawitz A, Mejia C, Templeton TJ (2004):
A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquito.
J Exp Med 199:1533-1544.

Pradel G, Frevert U (2001):
Malaria sporozoites actively enter and pass through rat Kupffer cells prior to hepatocyte invasion.
Hepatology 33:1154-1165.

Mota MM, Pradel G, Vanderberg JP, Hafalla JC, Frevert U, Nussenzweig RS, Nussenzweig V, Rodríguez A (2001):
Migration of Plasmodium sporozoites through cells before infection.
Science 291:141-144.

Thesis supervision

Primary supervisor 20 PhD theses, 11 diploma theses, 19 MSc theses, 16 BSc theses

Awards and Fellowships of co-workers

  • Dr. Sandra Bennink: Recipient of a Karman stipend of RWTH Aachen University, Germany, 2019.
  • Sandra Bennink: Junior Research Award of the DGHM-FG EP, 2018
  • Afia Farrukh: Recipient of a DAAD PhD fellowship, 2019-2021
  • Sandra Bennink: Recipient of the Junior Research Award of the German Society for Hygiene and Microbiology (DGHM-FG EP)
  • Jean Pierre Musabyimana: Recipient of a DAAD PhD fellowship, 2019-2021
  • Dr. Che Julius Ngwa: Recipient of the ERS Seed Fund of RWTH Aachen University, 2018
  • Monika Saini: Recipient of a DAAD PhD sandwich fellowship, 2017-2018
  • Thiago Rosa: Recipient of an EMBO short-term fellowship, 2017
  • Dr. Che Julius Ngwa: Recipient of a ERS Start Up grant of RWTH Aachen University, 2016
  • Ansgar Flammersfeld: Recipient of a poster award by the DGP, 2016
  • Dr. Bismarck Dinko: Recipient of a DAAD postdoc fellowship, 2015-2016
  • Emilie Joelle Njila Tchoufack: Recipient of a DAAD PhD fellowship, 2015-2019
  • Dr. Che Julius Ngwa: Recipient of a Karman stipend of RWTH Aachen University, 2014
  • Thiago Rosa: Recipient of a Science without Borders PhD fellowship, 2013-2017
  • Dr. Makoah Nigel Aminake: Recipient of a Georg Forster postdoctoral fellowship of the Alexander Humboldt Foundation, 2012-2014
  • Christine Wirth: Recipient of a poster award by the DGP, 2012
  • Nina Simon: Recipient of a Zonta Prize, Würzburg, Germany, 2010